A copper catalyzed multicomponent cascade redox reaction for the synthesis of quinazolinones

Mahesh H. Shinde; Umesh A. Kshirsagar

doi:10.1039/c6ra10997g

A copper catalyzed multicomponent cascade redox reaction for the synthesis of quinazolinones

Mahesh H. Shinde, Umesh A. Kshirsagar

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20 Scopus citations

Abstract

A copper catalyzed multicomponent cascade redox reaction for the synthesis of various quinazolinones starting from easily available 2-bromobenzamides, benzylic alcohols and sodium azide as a nitrogen source has been developed. The reaction involves copper catalyzed azidation of 2-bromobenzamide via an S_NAr reaction and oxidation of benzyl alcohol followed by sequential reduction-condensation-oxidation to produce quinazolinones.

Original language	English
Pages (from-to)	52884-52887
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	58
DOIs	https://doi.org/10.1039/c6ra10997g
State	Published - 1 Jan 2016
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c6ra10997g

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abstract = "A copper catalyzed multicomponent cascade redox reaction for the synthesis of various quinazolinones starting from easily available 2-bromobenzamides, benzylic alcohols and sodium azide as a nitrogen source has been developed. The reaction involves copper catalyzed azidation of 2-bromobenzamide via an SNAr reaction and oxidation of benzyl alcohol followed by sequential reduction-condensation-oxidation to produce quinazolinones.",

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AB - A copper catalyzed multicomponent cascade redox reaction for the synthesis of various quinazolinones starting from easily available 2-bromobenzamides, benzylic alcohols and sodium azide as a nitrogen source has been developed. The reaction involves copper catalyzed azidation of 2-bromobenzamide via an SNAr reaction and oxidation of benzyl alcohol followed by sequential reduction-condensation-oxidation to produce quinazolinones.

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A copper catalyzed multicomponent cascade redox reaction for the synthesis of quinazolinones

Abstract

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