A crayfish insulin-like-binding protein: Another piece in the androgenic gland insulin-like hormone puzzle is revealed

Ohad Rosen, Simy Weil, Rivka Manor, Ziv Roth, Isam Khalaila, Amir Sagi

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.

Original languageEnglish
Pages (from-to)22289-22298
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - 2 Aug 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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