A crayfish insulin-like-binding protein: Another piece in the androgenic gland insulin-like hormone puzzle is revealed

Ohad Rosen; Simy Weil; Rivka Manor; Ziv Roth; Isam Khalaila; Amir Sagi

doi:10.1074/jbc.M113.484279

A crayfish insulin-like-binding protein: Another piece in the androgenic gland insulin-like hormone puzzle is revealed

Ohad Rosen, Simy Weil, Rivka Manor, Ziv Roth, Isam Khalaila, Amir Sagi

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.

Original language	English
Pages (from-to)	22289-22298
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.484279
State	Published - 2 Aug 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.",

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AU - Weil, Simy

AU - Manor, Rivka

AU - Roth, Ziv

AU - Khalaila, Isam

AU - Sagi, Amir

PY - 2013/8/2

Y1 - 2013/8/2

N2 - Background: In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.

AB - Background: In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.

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A crayfish insulin-like-binding protein: Another piece in the androgenic gland insulin-like hormone puzzle is revealed

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