A cross-sectional survey on the preference of patients with rheumatoid arthritis for route of administration of disease-modifying anti-rheumatic drugs: Oral target-specific versus parenteral biologic

Yonatan Edel, Iftach Sagy, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Mohammad Egbaria, Shachaf Shiber, Bat Sheva Tal, Yair Molad

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Guidelines recommend initiation of parenteral biologic or oral target-specific disease-modifying anti-rheumatic drugs (bDMARDs/tsDMARDs) in rheumatoid arthritis (RA) patients who do not adequately respond to conventional DMARDs. Objectives: To compare the preferred route of administration of bDMARDs or tsDMARDs in RA patients who were previously treated with at least one type. Methods: A cross-sectional survey was conducted of consecutive RA patients previously prescribed bDMARDs or tsDMARDs. We analyzed the factors associated with patients’ preferred route of administration. Results: The cohort included 95 patients, mostly female (72.6%), seropositive (81.05%), mean age 63.4 ± 11.9 years. The oral route was preferred by 39 patients (41%) and 56 (59%) preferred the parenteral route. Most patients (65.9%) preferred to continue with their current route (P < 0.001). Switching from a current route was less common with patients who were currently using the oral route (13.3% vs. 38.2%, P = 0.04). Many patients (53.8%) who preferred the oral route had never experienced it before, while this was rare (3.6%) regarding the parenteral route (P = 0.0001). Employment status was associated with preference of the subcutaneous route over the intravenous route of bDMARDs (P = 0.01). Of the 21 patients who had previously experienced both parenteral and oral treatment, 16 (76.2%) preferred the oral route. Conclusions: RA patients preferred to continue treatment with an administration route they have already experienced. However, when choosing an unexperienced route, significantly more patients preferred the oral route. Our results strengthen the understanding of patient preferences, which could improve drug adherence, compliance, and disease outcome.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalIsrael Medical Association Journal
Volume22
Issue number3
StatePublished - 1 Mar 2020
Externally publishedYes

Keywords

  • Disease-modifying anti-rheumatic drugs (DMARDs)
  • Patient preference
  • Rheumatoid arthritis (RA)
  • Route of administration
  • Tofacitinib

ASJC Scopus subject areas

  • Medicine (all)

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