A de novo translocation, 14q21q, with a microchromosome, 14p21p

D. Abeliovich, M. Katz, M. Karplus, R. Carmi

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Abstract

A familial translocation, t(14;21)(14p21p;14q21q), in a mother and her child is described. The translocation was ascertained through the birth of a Down syndrome baby with the chromosome constitution 47,XX,-14,+der 14,+der 21,t(14;21)(q11;p12) mat. A 1:3 segregation in the maternal meiosis is suggested for the evolution of the unbalanced chromosome state. The main translocated chromosome 14q21q mimics the product of a Robertsonian translocation, while the 14p21p chromosome has the morphology of a satellited microchromosome. The cytogenetic nature of this translocation is discussed.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume22
Issue number1
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

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