A DNA-NDI Hybrid to Efficiently Detect Histone in Parts per Trillion (ppt) Level

Bapan Pramanik; Sahnawaz Ahmed; Rupam Roy; Basab K. Das; Nilotpal Singha; Debapratim Das

doi:10.1002/slct.201701888

A DNA-NDI Hybrid to Efficiently Detect Histone in Parts per Trillion (ppt) Level

Bapan Pramanik, Sahnawaz Ahmed, Rupam Roy, Basab K. Das, Nilotpal Singha, Debapratim Das

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI-DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn-on” the emission.

Original language	English
Pages (from-to)	8911-8916
Number of pages	6
Journal	ChemistrySelect
Volume	2
Issue number	28
DOIs	https://doi.org/10.1002/slct.201701888
State	Published - 29 Sep 2017
Externally published	Yes

Keywords

DNA
Histone
Intercalation
Naphthalenediimide
Sensor

ASJC Scopus subject areas

General Chemistry

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10.1002/slct.201701888

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title = "A DNA-NDI Hybrid to Efficiently Detect Histone in Parts per Trillion (ppt) Level",

abstract = "To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI-DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn-on” the emission.",

keywords = "DNA, Histone, Intercalation, Naphthalenediimide, Sensor",

author = "Bapan Pramanik and Sahnawaz Ahmed and Rupam Roy and Das, {Basab K.} and Nilotpal Singha and Debapratim Das",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Pramanik, Bapan

AU - Ahmed, Sahnawaz

AU - Roy, Rupam

AU - Das, Basab K.

AU - Singha, Nilotpal

AU - Das, Debapratim

PY - 2017/9/29

Y1 - 2017/9/29

N2 - To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI-DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn-on” the emission.

AB - To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI-DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn-on” the emission.

KW - DNA

KW - Histone

KW - Intercalation

KW - Naphthalenediimide

KW - Sensor

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ER -

A DNA-NDI Hybrid to Efficiently Detect Histone in Parts per Trillion (ppt) Level

Abstract

Keywords

ASJC Scopus subject areas

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