TY - JOUR
T1 - A gain-scheduling model predictive controller for blood glucose control in type 1 diabetes
AU - Abu-Rmileh, Amjad
AU - Garcia-Gabin, Winston
N1 - Funding Information:
Manuscript received June 9, 2009; revised August 10, 2009; accepted September 16, 2009. Date of publication October 20, 2009; date of current version September 15, 2010. This work was supported in part by the Spanish government under the Grants DPI-2007-66728-C02-01 and DPI-2007-66728-C02-02, by the European Union through FEDER funds and by the Catalan government under Grant SGR-00296, and the BR research grant of the University of Girona for the first author. Asterisk indicates corresponding author.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - This paper presents a control strategy for blood glucose (BG) level regulation in type 1 diabetic patients. To design the controller, model-based predictive control scheme has been applied to a newly developed diabetic patient model. The controller is provided with a feedforward loop to improve meal compensation, a gain-scheduling scheme to account for different BG levels, and an asymmetric cost function to reduce hypoglycemic risk. A simulation environment that has been approved for testing of artificial pancreas control algorithms has been used to test the controller. The simulation results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against model-patient mismatch and errors in meal estimation.
AB - This paper presents a control strategy for blood glucose (BG) level regulation in type 1 diabetic patients. To design the controller, model-based predictive control scheme has been applied to a newly developed diabetic patient model. The controller is provided with a feedforward loop to improve meal compensation, a gain-scheduling scheme to account for different BG levels, and an asymmetric cost function to reduce hypoglycemic risk. A simulation environment that has been approved for testing of artificial pancreas control algorithms has been used to test the controller. The simulation results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against model-patient mismatch and errors in meal estimation.
KW - Gain scheduling (GS)
KW - Model predictive control (MPC)
KW - Type 1 diabetes mellitus (T1DM)
UR - http://www.scopus.com/inward/record.url?scp=77956649906&partnerID=8YFLogxK
U2 - 10.1109/TBME.2009.2033663
DO - 10.1109/TBME.2009.2033663
M3 - Article
C2 - 19846371
AN - SCOPUS:77956649906
SN - 0018-9294
VL - 57
SP - 2478
EP - 2484
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10 PART 1
ER -
