A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol

Suman Pal; Joydev Hatai; Mousumi Samanta; Alok Shaurya; Subhajit Bandyopadhyay

doi:10.1039/c3ob42108b

A highly selective chemodosimeter for fast detection and intracellular imaging of Hg²⁺ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol

Suman Pal, Joydev Hatai, Mousumi Samanta, Alok Shaurya, Subhajit Bandyopadhyay

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A new naphthalene diimide-dithiocarbamate based fluorescence probe was synthesized and its fluorogenic behavior towards various metal ions was studied. Upon addition of various metal ions, the probe afforded an irreversible change only with Hg²⁺ ions in aqueous-ethanol media (4:1 v/v) with a fourfold enhancement of the fluorescence (Φ = 0.03 → 0.11) along with a distinct 43 nm blue shift of the emission maxima. The mechanism of the chemodosimetric behavior of the probe has been attributed to a Hg²⁺ induced transformation of a weakly fluorescent dithiocarbamate to a highly fluorescent isothiocyanate which has been characterized by a number of spectroscopic techniques and a crystal structure. Intracellular detection of Hg²⁺ ions was achieved using the probe.

Original language	English
Pages (from-to)	1072-1078
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	7
DOIs	https://doi.org/10.1039/c3ob42108b
State	Published - 21 Feb 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol",

abstract = "A new naphthalene diimide-dithiocarbamate based fluorescence probe was synthesized and its fluorogenic behavior towards various metal ions was studied. Upon addition of various metal ions, the probe afforded an irreversible change only with Hg2+ ions in aqueous-ethanol media (4:1 v/v) with a fourfold enhancement of the fluorescence (Φ = 0.03 → 0.11) along with a distinct 43 nm blue shift of the emission maxima. The mechanism of the chemodosimetric behavior of the probe has been attributed to a Hg2+ induced transformation of a weakly fluorescent dithiocarbamate to a highly fluorescent isothiocyanate which has been characterized by a number of spectroscopic techniques and a crystal structure. Intracellular detection of Hg2+ ions was achieved using the probe.",

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T1 - A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol

AU - Pal, Suman

AU - Hatai, Joydev

AU - Samanta, Mousumi

AU - Shaurya, Alok

AU - Bandyopadhyay, Subhajit

PY - 2014/2/21

Y1 - 2014/2/21

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AB - A new naphthalene diimide-dithiocarbamate based fluorescence probe was synthesized and its fluorogenic behavior towards various metal ions was studied. Upon addition of various metal ions, the probe afforded an irreversible change only with Hg2+ ions in aqueous-ethanol media (4:1 v/v) with a fourfold enhancement of the fluorescence (Φ = 0.03 → 0.11) along with a distinct 43 nm blue shift of the emission maxima. The mechanism of the chemodosimetric behavior of the probe has been attributed to a Hg2+ induced transformation of a weakly fluorescent dithiocarbamate to a highly fluorescent isothiocyanate which has been characterized by a number of spectroscopic techniques and a crystal structure. Intracellular detection of Hg2+ ions was achieved using the probe.

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A highly selective chemodosimeter for fast detection and intracellular imaging of Hg²⁺ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol

Abstract

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