A humoral solution: Autologous blood products and tissue repair

Yuval Yogev

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Autologous blood-derived products (ABP) are the focus of growing scientific interest and are investigated and used for multiple medical indications. ABPs hold promise thanks to their availability, ease of preparation, and low risk of adverse allogenic reaction, hypersensitivity, and contamination. Compositional analysis of ABPs reveals a diverse mixture of cellular components, cytokines and growth factors that play roles in healing processes such as tissue proliferation and angiogenesis, modulation of the local environment through chemotaxis and regulation of inflammation and the extracellular matrix, as well as several immunomodulatory actions. Thus, the administration of ABP induces supraphysiological levels of components necessary for orchestrating reparative efforts in currently difficult-to-treat medical conditions. In this article, we review the variety of autologous blood-derived products, their composition, current clinical uses, regulatory climate, and mechanisms of action.

Original languageEnglish
Article number104178
JournalCellular Immunology
Volume356
DOIs
StatePublished - 1 Oct 2020

Keywords

  • Autologous blood
  • Autologous serum
  • Autotransfusion
  • Cytokines
  • Growth factors
  • Infusion medicine
  • Ozone therapy
  • Platelet-rich plasma
  • UV blood irradiation
  • Wound healing

ASJC Scopus subject areas

  • Immunology

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