TY - JOUR
T1 - A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation
AU - Palermo, Amelia
AU - Li, Shen
AU - ten Hoeve, Johanna
AU - Chellappa, Akshay
AU - Morris, Alexandra
AU - Dillon, Barbara
AU - Ma, Feiyang
AU - Wang, Yijie
AU - Cao, Edward
AU - Shabane, Byourak
AU - Acín-Perez, Rebeca
AU - Petcherski, Anton
AU - Lusis, A. Jake
AU - Hazen, Stanley
AU - Shirihai, Orian S.
AU - Pellegrini, Matteo
AU - Arumugaswami, Vaithilingaraja
AU - Graeber, Thomas G.
AU - Deb, Arjun
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism.
AB - The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85175736842&partnerID=8YFLogxK
U2 - 10.1038/s42003-023-05478-7
DO - 10.1038/s42003-023-05478-7
M3 - Article
C2 - 37923961
AN - SCOPUS:85175736842
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1115
ER -
