A large open reading frame (orf1995) in the chloroplast DNA of Chlamydomonas reinhardtii encodes an essential protein

  • E. Boudreau
  • , M. Turmel
  • , M. Goldschmidt-Clermont
  • , J. D. Rochaix
  • , S. Sivan
  • , A. Michaels
  • , S. Leu

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

An open reading frame potentially encoding a protein of 1995 amino acids (orf1995) has been found in the chloroplast genome of the green alga Chlamydomonas reinhardtii. Besides having a short hydrophobic N-terminal domain with five putative transmembrane helices, the predicted orf1995 product is highly basic. orf1995 might be a homologue of the ycf1 gene in land plants, whose function has not yet been determined. Mutants of C. reinhardtii transformed with a disruption of orf1995 remain heteroplasmic for the wild-type and disrupted alleles of this gene, indicating that the orf1995 product is essential for cell survival.

Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalMolecular and General Genetics
Volume253
Issue number5
DOIs
StatePublished - 18 Mar 1997

Keywords

  • Chlamydomonas reinhardtii
  • Chloroplast genome
  • Gene activation
  • Green algae
  • Transmembrane protein

ASJC Scopus subject areas

  • Genetics

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