A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg; Aviya Dvir Ifrah; Tzipi Strauss; Michal J. Simchen; Raoul Orvieto; Nurit Rosenberg; Gili Kenet

doi:10.1002/pbc.26447

A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg, Aviya Dvir Ifrah, Tzipi Strauss, Michal J. Simchen, Raoul Orvieto, Nurit Rosenberg, Gili Kenet

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

Original language	English
Article number	e26447
Journal	Pediatric Blood and Cancer
Volume	64
Issue number	8
DOIs	https://doi.org/10.1002/pbc.26447
State	Published - 1 Aug 2017
Externally published	Yes

Keywords

HPA
Turner syndrome
neonatal thrombocytopenia
oocyte donor
surrogate pregnancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.26447

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abstract = "The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.",

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AU - Simchen, Michal J.

AU - Orvieto, Raoul

AU - Rosenberg, Nurit

AU - Kenet, Gili

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AB - The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

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A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Abstract

Keywords

ASJC Scopus subject areas

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