A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg, Aviya Dvir Ifrah, Tzipi Strauss, Michal J. Simchen, Raoul Orvieto, Nurit Rosenberg, Gili Kenet

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

Original languageEnglish
Article numbere26447
JournalPediatric Blood and Cancer
Volume64
Issue number8
DOIs
StatePublished - 1 Aug 2017
Externally publishedYes

Keywords

  • HPA
  • Turner syndrome
  • neonatal thrombocytopenia
  • oocyte donor
  • surrogate pregnancy

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