A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg; Aviya Dvir Ifrah; Tzipi Strauss; Michal J. Simchen; Raoul Orvieto; Nurit Rosenberg; Gili Kenet

doi:10.1002/pbc.26447

A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg
, Aviya Dvir Ifrah
, Tzipi Strauss
, Michal J. Simchen
, Raoul Orvieto
, Nurit Rosenberg
, Gili Kenet

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

Original language	English
Article number	e26447
Journal	Pediatric Blood and Cancer
Volume	64
Issue number	8
DOIs	https://doi.org/10.1002/pbc.26447
State	Published - 1 Aug 2017
Externally published	Yes

Keywords

HPA
Turner syndrome
neonatal thrombocytopenia
oocyte donor
surrogate pregnancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.26447

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title = "A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother",

abstract = "The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.",

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AU - Ifrah, Aviya Dvir

AU - Strauss, Tzipi

AU - Simchen, Michal J.

AU - Orvieto, Raoul

AU - Rosenberg, Nurit

AU - Kenet, Gili

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AB - The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

KW - HPA

KW - Turner syndrome

KW - neonatal thrombocytopenia

KW - oocyte donor

KW - surrogate pregnancy

UR - https://www.scopus.com/pages/publications/85020621748

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IS - 8

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ER -

A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Abstract

Keywords

ASJC Scopus subject areas

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