A mathematical model of baculovirus infection on insect cells at low multiplicity of infection

You Hong Zhang, José C. Merchuk

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The expression efficiency of the insect cells-baculovirus system used for insecticidal virus production and the expression of medically useful foreign genes is closely related with the dynamics of infection. The present studies develop a model of the dynamic process of insect cell infection with baculovirus at low multiplicity of infection (MOI), which is based on the multi-infection cycles of insect cell infection at low MOI. A mathematical model for the amount of viruses released from primary infected cells and the amount of free viruses before secondary infected cells release viruses has been developed. Comparison of the simulation results with the experimental data confirms qualitatively that this model is highly reasonable before secondary infected cells release viruses. This model is considered as a base for further modeling the entire complicated infection process.

Original languageEnglish
Pages (from-to)729-740
Number of pages12
JournalActa Biochimica et Biophysica Sinica
Volume36
Issue number11
DOIs
StatePublished - 1 Jan 2004

Keywords

  • Baculovirus
  • Infection
  • Insect cells
  • Modeling
  • Multiplicity of infection (MOI)

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