A mechanistic approach to understanding oral drug absorption in pediatrics: An overview of fundamentals

Nir Debotton, Arik Dahan

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The common phrase 'children are not little adults' is very true also in the field of oral drug administration and absorption. However, in practice, due to the little available data and lack of in-depth understanding, physicians may treat kids as if they were 'little adults', even without being aware of the potential differences and risks. With respect to drug discovery, research and development, an in-depth understanding of the various factors governing age-dependent absorption is crucial when trying to develop a pediatric-tailored oral drug product. In this paper we clarify the various mechanisms that may lead to age-dependent oral drug absorption, we provide an overview of the currently available data, and draw conclusions to the coming years.

Original languageEnglish
Pages (from-to)1322-1336
Number of pages15
JournalDrug Discovery Today
Volume19
Issue number9
DOIs
StatePublished - 1 Jan 2014

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