A metric test for assessing spatial working memory in adult rats following traumatic brain injury

Dmitry Frank, Benjamin F. Gruenbaum, Israel Melamed, Julia Grinshpun, Yair Benjamin, Ievgeni Vzhetson, Nadia Kravchenko, Michael Dubilet, Matthew Boyko, Alexander Zlotnik

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of human studies, animal models provide suitable alternatives to test treatment methods, and to study the mechanisms and related complications of the condition. Experimental rodent models have historically been the most widely used due to their accessibility, low cost, reproducibility, and validated approaches. A metric test, which tests the ability to recall the placement of two objects at various distances and angles from one another, is a technique to study impairment in spatial working memory (SWM) after TBI. The significant advantages of metric tasks include the possibility of dynamic observation, low cost, reproducibility, relative ease of implementation, and low stress environment. Here, we present a metric test protocol to measure impairment of SWM in adult rats after TBI. This test provides a feasible way to evaluate physiology and pathophysiology of brain function more effectively.

Original languageEnglish
Article numbere62291
JournalJournal of Visualized Experiments
Issue number171
StatePublished - 1 Jan 2021

ASJC Scopus subject areas

  • Neuroscience (all)
  • Chemical Engineering (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)


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