TY - JOUR
T1 - A metric test for assessing spatial working memory in adult rats following traumatic brain injury
AU - Frank, Dmitry
AU - Gruenbaum, Benjamin F.
AU - Melamed, Israel
AU - Grinshpun, Julia
AU - Benjamin, Yair
AU - Vzhetson, Ievgeni
AU - Kravchenko, Nadia
AU - Dubilet, Michael
AU - Boyko, Matthew
AU - Zlotnik, Alexander
N1 - Publisher Copyright:
© 2021 JoVE Journal of Visualized Experiments.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of human studies, animal models provide suitable alternatives to test treatment methods, and to study the mechanisms and related complications of the condition. Experimental rodent models have historically been the most widely used due to their accessibility, low cost, reproducibility, and validated approaches. A metric test, which tests the ability to recall the placement of two objects at various distances and angles from one another, is a technique to study impairment in spatial working memory (SWM) after TBI. The significant advantages of metric tasks include the possibility of dynamic observation, low cost, reproducibility, relative ease of implementation, and low stress environment. Here, we present a metric test protocol to measure impairment of SWM in adult rats after TBI. This test provides a feasible way to evaluate physiology and pathophysiology of brain function more effectively.
AB - Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of human studies, animal models provide suitable alternatives to test treatment methods, and to study the mechanisms and related complications of the condition. Experimental rodent models have historically been the most widely used due to their accessibility, low cost, reproducibility, and validated approaches. A metric test, which tests the ability to recall the placement of two objects at various distances and angles from one another, is a technique to study impairment in spatial working memory (SWM) after TBI. The significant advantages of metric tasks include the possibility of dynamic observation, low cost, reproducibility, relative ease of implementation, and low stress environment. Here, we present a metric test protocol to measure impairment of SWM in adult rats after TBI. This test provides a feasible way to evaluate physiology and pathophysiology of brain function more effectively.
UR - http://www.scopus.com/inward/record.url?scp=85107081946&partnerID=8YFLogxK
U2 - 10.3791/62291
DO - 10.3791/62291
M3 - Article
C2 - 34028433
AN - SCOPUS:85107081946
SN - 1940-087X
VL - 2021
JO - Journal of Visualized Experiments
JF - Journal of Visualized Experiments
IS - 171
M1 - e62291
ER -