TY - GEN
T1 - A miniaturized system for imaging vascular response to deep brain stimulation
AU - Zhang, Xiao
AU - Noor, Muhammad S.
AU - McCracken, Clinton B.
AU - Kiss, Zelma H.T.
AU - Yadid-Pecht, Orly
AU - Murari, Kartikeya
PY - 2013/12/1
Y1 - 2013/12/1
N2 - We present a miniaturized system for spectroscopic imaging of the cerebrovascular response to deep brain stimulation (DBS). The system consists of an optical module with controllable light emitting diode (LED) illumination and focusing optics, and an electronic module with a high-sensitivity complementary metal oxide semiconductor (CMOS) image sensor, an off-chip controller and a microSD card for image storage. The system is a refinement of our previously described integrated imaging microscope (IIM). Key differences include a further reduced footprint with the head-stage occupying less than 1.5 cm3 and weighing under 1.5 gm, pulse width modulation (PWM) control of illumination intensity and improved signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) performance. Electrical and optical characterization and simulation data, and experimental data from an anesthetized rat are presented. Combined with integrated instrumentation for electrical stimulation and electrophysiology, we expect the tether-free, animal mountable system to facilitate understanding the long-term vascular and electrical effects of deep brain stimulation in freely-moving animals.
AB - We present a miniaturized system for spectroscopic imaging of the cerebrovascular response to deep brain stimulation (DBS). The system consists of an optical module with controllable light emitting diode (LED) illumination and focusing optics, and an electronic module with a high-sensitivity complementary metal oxide semiconductor (CMOS) image sensor, an off-chip controller and a microSD card for image storage. The system is a refinement of our previously described integrated imaging microscope (IIM). Key differences include a further reduced footprint with the head-stage occupying less than 1.5 cm3 and weighing under 1.5 gm, pulse width modulation (PWM) control of illumination intensity and improved signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) performance. Electrical and optical characterization and simulation data, and experimental data from an anesthetized rat are presented. Combined with integrated instrumentation for electrical stimulation and electrophysiology, we expect the tether-free, animal mountable system to facilitate understanding the long-term vascular and electrical effects of deep brain stimulation in freely-moving animals.
UR - http://www.scopus.com/inward/record.url?scp=84893523258&partnerID=8YFLogxK
U2 - 10.1109/BioCAS.2013.6679655
DO - 10.1109/BioCAS.2013.6679655
M3 - Conference contribution
AN - SCOPUS:84893523258
SN - 9781479914715
T3 - 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
SP - 126
EP - 129
BT - 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
T2 - 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
Y2 - 31 October 2013 through 2 November 2013
ER -