Abstract
Electrophysiological properties of cardiac tissue change as a function of position. We define the 'excitability' as the propagation velocity of an excitation pulse through the tissue, and study a simple FitzHugh-Nagumo (FHN) model of heart tissue whose excitability changes with position. The propagation velocity is shown to be a good continuous measure of the excitability for both limit cycle and excitable tissues. The influence of the spatial dependence of the excitability is examined for several normal and pathological situations. A novel transient effect is observed for a train of pulses propagating across an excitability step.
Original language | English |
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Pages (from-to) | 141-154 |
Number of pages | 14 |
Journal | Journal of Theoretical Biology |
Volume | 196 |
Issue number | 2 |
DOIs | |
State | Published - 21 Jan 1999 |
ASJC Scopus subject areas
- Statistics and Probability
- Modeling and Simulation
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
- General Agricultural and Biological Sciences
- Applied Mathematics