TY - JOUR
T1 - A national survey of the molecular epidemiology of Clostridium difficile in Israel
T2 - The dissemination of the ribotype 027 strain with reduced susceptibility to vancomycin and metronidazole
AU - Adler, Amos
AU - Miller-Roll, Tamar
AU - Bradenstein, Rita
AU - Block, Colin
AU - Mendelson, Bracha
AU - Parizade, Miriam
AU - Paitan, Yossi
AU - Schwartz, David
AU - Peled, Nehama
AU - Carmeli, Yehuda
AU - Schwaber, Mitchell J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Our goals were to study the molecular epidemiology and antimicrobial susceptibilities of C. difficile strains in Israel. Microbiology laboratories serving 6 general hospitals (GH) and 10 long-term care facilities (LTCF) were asked to submit all stool samples in January-February 2014 that tested positive for C. difficile. Toxigenic C. difficile isolates were recovered in 208 out of 217 samples (95.8%), of which 50 (23.6%) were from LTCFs. Ribotype 027 was the most common type overall, identified in 65 samples (31.8%), and was the predominant strain in the 3 GHs with the highest incidence of C. difficile infections. Other common strains were slpA types cr-02 (n. =. 45) and hr-02 (n. =. 18). The proportions of vancomycin and metronidazole MIC values >2. mg/L were high in ribotype 027 (87.7% and 44.6%, respectively) and slpA-cr-02 strains (88.8% and 17.8%, respectively). This study demonstrates that the ribotype 027 strain has disseminated across Israel and is now the most common strain.
AB - Our goals were to study the molecular epidemiology and antimicrobial susceptibilities of C. difficile strains in Israel. Microbiology laboratories serving 6 general hospitals (GH) and 10 long-term care facilities (LTCF) were asked to submit all stool samples in January-February 2014 that tested positive for C. difficile. Toxigenic C. difficile isolates were recovered in 208 out of 217 samples (95.8%), of which 50 (23.6%) were from LTCFs. Ribotype 027 was the most common type overall, identified in 65 samples (31.8%), and was the predominant strain in the 3 GHs with the highest incidence of C. difficile infections. Other common strains were slpA types cr-02 (n. =. 45) and hr-02 (n. =. 18). The proportions of vancomycin and metronidazole MIC values >2. mg/L were high in ribotype 027 (87.7% and 44.6%, respectively) and slpA-cr-02 strains (88.8% and 17.8%, respectively). This study demonstrates that the ribotype 027 strain has disseminated across Israel and is now the most common strain.
KW - Clostridium difficile
KW - Epidemic clone
KW - Metronidazole
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=84938746151&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2015.05.015
DO - 10.1016/j.diagmicrobio.2015.05.015
M3 - Article
C2 - 26116225
AN - SCOPUS:84938746151
SN - 0732-8893
VL - 83
SP - 21
EP - 24
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -