A new route to indoles via in situ desilylation-Sonogashira strategy: Identification of novel small molecules as potential anti-tuberculosis agents

Ali Nakhi; Bagineni Prasad; Uppender Reddy; Raja Mohan Rao; Sandhya Sandra; Ravikumar Kapavarapu; D. Rambabu; G. Rama Krishna; C. Malla Reddy; Kishore Ravada; Parimal Misra; Javed Iqbal; Manojit Pal

doi:10.1039/c1md00148e

A new route to indoles via in situ desilylation-Sonogashira strategy: Identification of novel small molecules as potential anti-tuberculosis agents

Ali Nakhi, Bagineni Prasad, Uppender Reddy, Raja Mohan Rao, Sandhya Sandra, Ravikumar Kapavarapu, D. Rambabu, G. Rama Krishna, C. Malla Reddy, Kishore Ravada, Parimal Misra, Javed Iqbal, Manojit Pal

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO ₂NH)C ₆H ₄ group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.

Original language	English
Pages (from-to)	1006-1010
Number of pages	5
Journal	MedChemComm
Volume	2
Issue number	10
DOIs	https://doi.org/10.1039/c1md00148e
State	Published - 1 Oct 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c1md00148e

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Nakhi, A., Prasad, B., Reddy, U., Rao, R. M., Sandra, S., Kapavarapu, R., Rambabu, D., Rama Krishna, G., Reddy, C. M., Ravada, K., Misra, P., Iqbal, J., & Pal, M. (2011). A new route to indoles via in situ desilylation-Sonogashira strategy: Identification of novel small molecules as potential anti-tuberculosis agents. MedChemComm, 2(10), 1006-1010. https://doi.org/10.1039/c1md00148e

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abstract = "A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO 2NH)C 6H 4 group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.",

author = "Ali Nakhi and Bagineni Prasad and Uppender Reddy and Rao, \{Raja Mohan\} and Sandhya Sandra and Ravikumar Kapavarapu and D. Rambabu and \{Rama Krishna\}, G. and Reddy, \{C. Malla\} and Kishore Ravada and Parimal Misra and Javed Iqbal and Manojit Pal",

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doi = "10.1039/c1md00148e",

language = "English",

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Nakhi, A, Prasad, B, Reddy, U, Rao, RM, Sandra, S, Kapavarapu, R, Rambabu, D, Rama Krishna, G, Reddy, CM, Ravada, K, Misra, P, Iqbal, J & Pal, M 2011, 'A new route to indoles via in situ desilylation-Sonogashira strategy: Identification of novel small molecules as potential anti-tuberculosis agents', MedChemComm, vol. 2, no. 10, pp. 1006-1010. https://doi.org/10.1039/c1md00148e

TY - JOUR

T1 - A new route to indoles via in situ desilylation-Sonogashira strategy

T2 - Identification of novel small molecules as potential anti-tuberculosis agents

AU - Nakhi, Ali

AU - Prasad, Bagineni

AU - Reddy, Uppender

AU - Rao, Raja Mohan

AU - Sandra, Sandhya

AU - Kapavarapu, Ravikumar

AU - Rambabu, D.

AU - Rama Krishna, G.

AU - Reddy, C. Malla

AU - Ravada, Kishore

AU - Misra, Parimal

AU - Iqbal, Javed

AU - Pal, Manojit

PY - 2011/10/1

Y1 - 2011/10/1

N2 - A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO 2NH)C 6H 4 group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.

AB - A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO 2NH)C 6H 4 group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase in vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.

UR - https://www.scopus.com/pages/publications/80053610027

U2 - 10.1039/c1md00148e

DO - 10.1039/c1md00148e

M3 - Article

AN - SCOPUS:80053610027

SN - 2040-2503

VL - 2

SP - 1006

EP - 1010

JO - MedChemComm

JF - MedChemComm

IS - 10

ER -

A new route to indoles via in situ desilylation-Sonogashira strategy: Identification of novel small molecules as potential anti-tuberculosis agents

Abstract

ASJC Scopus subject areas

UN SDGs

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