A new strategy for improved nicotine vaccines using conformationally constrained haptens

Michael M. Meijler; Masayuki Matsushita; Laurence J. Altobell; Peter Wirsching; Kim D. Janda

doi:10.1021/ja034805t

A new strategy for improved nicotine vaccines using conformationally constrained haptens

Michael M. Meijler, Masayuki Matsushita, Laurence J. Altobell, Peter Wirsching, Kim D. Janda

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

Original language	English
Pages (from-to)	7164-7165
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	24
DOIs	https://doi.org/10.1021/ja034805t
State	Published - 18 Jun 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja034805t

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title = "A new strategy for improved nicotine vaccines using conformationally constrained haptens",

abstract = "Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.",

author = "Meijler, {Michael M.} and Masayuki Matsushita and Altobell, {Laurence J.} and Peter Wirsching and Janda, {Kim D.}",

year = "2003",

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AU - Meijler, Michael M.

AU - Matsushita, Masayuki

AU - Altobell, Laurence J.

AU - Wirsching, Peter

AU - Janda, Kim D.

PY - 2003/6/18

Y1 - 2003/6/18

N2 - Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

AB - Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

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U2 - 10.1021/ja034805t

DO - 10.1021/ja034805t

M3 - Article

AN - SCOPUS:0038789010

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 24

ER -

A new strategy for improved nicotine vaccines using conformationally constrained haptens

Abstract

ASJC Scopus subject areas

UN SDGs

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