A Novel Agarose Acrobeads Protein A Column for Selective Immunoadsorbance of Whole Blood: Performance, Specificity and Safety

I. Nathan, M. Aharon, G. Reisenfeld, A. Dvilansky

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The present study describes the performance and safety parameters of a novel column composed of protein A linked to acrobeads. Hemoperfusion of anticoagulated whole human blood was carried out in a closed system. Specific adsorption of IgG was documented in whole blood, plasma and IgG diluted in saline. Specific activity of the column was 3.52 mg/ml beads. These studies revealed slight changes in platelet counts and minor hemolysis. The relatively short period needed for maximal hemoperfusion effect and safety may enable the use of this novel therapeutic approach in clinical practice.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume20
Issue number1
DOIs
StatePublished - 1 Jan 1992

ASJC Scopus subject areas

  • Medicine (all)

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