A novel combined score of biomarkers in sputum may be an indicator for lung cancer: A pilot study

Amir Bar-Shai, Shani Shenhar-Tsarfaty, Alon Ahimor, Noa Ophir, Michal Rotem, Yifat Alcalay, Elizabeth Fireman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Lung cancer is a leading cause of morbidity and mortality worldwide and there is an urgent need for sensitive, specific, and reliable biomarkers. Methods: The study population included 60 patients (31 with lung cancer and 29 with chronic obstructive pulmonary disease [COPD]) and thirty healthy individuals comprised the control group. Measurements of neutrophil, beclin-1, VEGF, ICAM, VCAM, and TNF-alpha levels in induced sputum were analyzed as possible biomarkers for lung cancer. Results: Neutrophil, beclin-1, VEGF, ICAM and TNF-alpha levels of lung cancer patients differed significantly compared to those of COPD patients and healthy controls. A novel combined-score was created which was found to increase the likelihood to belong to the cancer group by 70% (odds-ratio 1.70 CI = 1.310–2.224,p < 0.001). Conclusion: Biomarkers of autophagy, angiogenesis and inflammation in lung-cancer patients are significantly different from controls, and combination of these markers may be an indicator for lung cancer.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalClinica Chimica Acta
Volume487
DOIs
StatePublished - 1 Dec 2018

Keywords

  • Angiogenesis
  • Biomarkers
  • Inflammation
  • Screening

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