A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Benyamin Rosental, Uzi Hadad, Michael Brusilovsky, Kerry S. Campbell, Angel Porgador

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.

Original languageEnglish
Pages (from-to)572-574
Number of pages3
JournalOncoImmunology
Volume1
Issue number4
DOIs
StatePublished - 2 Nov 2012

Keywords

  • ITIM
  • Inhibitory ligand
  • NCR
  • NK cells
  • NKp44
  • PCNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Fingerprint

Dive into the research topics of 'A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen'. Together they form a unique fingerprint.

Cite this