A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Benyamin Rosental; Uzi Hadad; Michael Brusilovsky; Kerry S. Campbell; Angel Porgador

doi:10.4161/onci.19366

A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Benyamin Rosental, Uzi Hadad, Michael Brusilovsky, Kerry S. Campbell, Angel Porgador

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.

Original language	English
Pages (from-to)	572-574
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/onci.19366
State	Published - 2 Nov 2012

Keywords

ITIM
Inhibitory ligand
NCR
NK cells
NKp44
PCNA

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.19366

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abstract = "We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.",

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AU - Hadad, Uzi

AU - Brusilovsky, Michael

AU - Campbell, Kerry S.

AU - Porgador, Angel

PY - 2012/11/2

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AB - We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.

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KW - Inhibitory ligand

KW - NCR

KW - NK cells

KW - NKp44

KW - PCNA

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A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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