A novel micro-fluidic whole cell biosensor for water toxicity analysis using bioluminescence detection

Hadar Ben-Yoav, Svyatoslav Yorish, Tal Elad, Sefi Vernick, Shimshon Belkin, Yosi Shacham-Diamand

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A novel micro-fluidic whole cell biosensor for toxicity analysis based on bioluminescence detection was developed. The optical part of the biochip was modelled and simulated to optimize the total light collection efficiency and the system response. The optimization elucidated some of the optical aspects of the biochip. A study evaluating the bioluminescence reaction kinetics was performed and revealed the interdependence between the detected bioluminescence and the physical parameters of the introduced toxin.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1049-1052
Number of pages4
ISBN (Electronic)9780979806407
StatePublished - 1 Jan 2007
Externally publishedYes
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 7 Oct 200711 Oct 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period7/10/0711/10/07

Keywords

  • Bioluminescence
  • Stray light analysis
  • Water toxicity
  • Whole-cell biosensor

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