A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

Suresh Babu Nallapati; Raju Adepu; Mohd Ashraf Ashfaq; B. Yogi Sreenivas; K. Mukkanti; Manojit Pal

doi:10.1039/c5ra17908d

A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

Suresh Babu Nallapati, Raju Adepu, Mohd Ashraf Ashfaq, B. Yogi Sreenivas, K. Mukkanti, Manojit Pal

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.

Original language	English
Pages (from-to)	88686-88691
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	108
DOIs	https://doi.org/10.1039/c5ra17908d
State	Published - 1 Jan 2015
Externally published	Yes

ASJC Scopus subject areas

Chemistry (all)
Chemical Engineering (all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c5ra17908d

Cite this

@article{c3297e2cfd0849dfa0766f27f334ac64,

title = "A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents",

abstract = "We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.",

author = "Nallapati, {Suresh Babu} and Raju Adepu and Ashfaq, {Mohd Ashraf} and Sreenivas, {B. Yogi} and K. Mukkanti and Manojit Pal",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = jan,

day = "1",

doi = "10.1039/c5ra17908d",

language = "English",

volume = "5",

pages = "88686--88691",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "108",

}

TY - JOUR

T1 - A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

AU - Nallapati, Suresh Babu

AU - Adepu, Raju

AU - Ashfaq, Mohd Ashraf

AU - Sreenivas, B. Yogi

AU - Mukkanti, K.

AU - Pal, Manojit

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.

AB - We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.

UR - http://www.scopus.com/inward/record.url?scp=84945250390&partnerID=8YFLogxK

U2 - 10.1039/c5ra17908d

DO - 10.1039/c5ra17908d

M3 - Article

AN - SCOPUS:84945250390

SN - 2046-2069

VL - 5

SP - 88686

EP - 88691

JO - RSC Advances

JF - RSC Advances

IS - 108

ER -

A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this