A [Pd]-mediated ω-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A

Sachin B. Narute; Neella Chandra Kiran; Chepuri V. Ramana

doi:10.1039/c1ob05251a

A [Pd]-mediated ω-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A

Sachin B. Narute
, Neella Chandra Kiran
, Chepuri V. Ramana

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented.

Original language	English
Pages (from-to)	5469-5475
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	15
DOIs	https://doi.org/10.1039/c1ob05251a
State	Published - 7 Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c1ob05251a

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title = "A [Pd]-mediated ω-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A",

abstract = "A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented.",

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AU - Narute, Sachin B.

AU - Kiran, Neella Chandra

AU - Ramana, Chepuri V.

PY - 2011/8/7

Y1 - 2011/8/7

N2 - A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented.

AB - A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented.

UR - https://www.scopus.com/pages/publications/79960382300

U2 - 10.1039/c1ob05251a

DO - 10.1039/c1ob05251a

M3 - Article

C2 - 21670840

AN - SCOPUS:79960382300

SN - 1477-0520

VL - 9

SP - 5469

EP - 5475

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 15

ER -

A [Pd]-mediated ω-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A

Abstract

ASJC Scopus subject areas

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