A pivotal role for the Streptococcus iniae extracellular polysaccharide in triggering proinflammatory cytokines transcription and inducing death in rainbow trout

Marina Eyngor, Avishay Lublin, Roni Shapira, Avshalom Hurvitz, Amir Zlotkin, Yoram Tekoah, Avi Eldar

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Streptococcus iniae is a major pathogen of fish, causing considerable economic losses in Israel, the United States and the Far East. Containment of mortalities through vaccination was recently compromised due to the emergence of novel vaccine-escape strains that are distinguished from previous strains by their ability to produce large amounts of extracellular polysaccharide (EPS) that is released to the medium. In vitro and in vivo data now indicate that the EPS is a major virulence factor, capable of triggering the proinflammatory cytokine machinery and inducing mortality of fish. Streptococcus iniae EPS might therefore be considered to be responsible for sepsis and death just as lipopolysaccharide is for Gram-negative pathogens.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalFEMS Microbiology Letters
Volume305
Issue number2
DOIs
StatePublished - 1 Jan 2010

Keywords

  • Cytokines
  • Extracellular polysaccharide
  • Fish
  • Proinflammation
  • Streptococcus iniae

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