A practical and convenient protocol for the synthesis of (E)-α,β-unsaturated acids

Amar R. Mohite, Ramakrishna G. Bhat

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

α,β-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3·6H2O (0.5 mol %) and H 2O (1 equiv) in CH3NO2 is described for the rapid synthesis of α,β-unsaturated acids with high E-stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass derived aldehydes to build chemical agents used as fuel additives. The method proved to be scalable to gram scale synthesis.

Original languageEnglish
Pages (from-to)4564-4567
Number of pages4
JournalOrganic Letters
Volume15
Issue number17
DOIs
StatePublished - 6 Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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