TY - JOUR
T1 - A preliminary study of intravenous methanol extraction residue of bcg in treatment of advanced cancer
AU - Robinson, E.
AU - Bartal, A.
AU - Honigman, J.
AU - Cohen, Y.
N1 - Funding Information:
This work was supported in part by a donation in memory of the late Luise Guterman, administered by the Office of the Administrator General, Ministry of Justice and the Medical Research Fund under the sponsorship of the Ministry of Health.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was evaluated in the patients. All patients except 4 were anergic. Twelve patients had no side-effects. Anergic patients had less side-effects than ergic patients. The side-effects recorded in the others were fever, chills, vomiting and tachycardia. The reaction subsided within 24 h after treatment and was tolerable for most patients. In 2 patients an objective improvement was observed. No changes in cutaneous reactivity, renal and hepatic functions were found. A significant increase in peripheral leucocyte count was noted in two patients and slight a increase in the remainder.
AB - Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was evaluated in the patients. All patients except 4 were anergic. Twelve patients had no side-effects. Anergic patients had less side-effects than ergic patients. The side-effects recorded in the others were fever, chills, vomiting and tachycardia. The reaction subsided within 24 h after treatment and was tolerable for most patients. In 2 patients an objective improvement was observed. No changes in cutaneous reactivity, renal and hepatic functions were found. A significant increase in peripheral leucocyte count was noted in two patients and slight a increase in the remainder.
UR - http://www.scopus.com/inward/record.url?scp=0017738022&partnerID=8YFLogxK
U2 - 10.1038/bjc.1977.198
DO - 10.1038/bjc.1977.198
M3 - Article
C2 - 336070
AN - SCOPUS:0017738022
SN - 0007-0920
VL - 36
SP - 341
EP - 346
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 3
ER -
