A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients

Y. Bersudsky, M. Kotler, M. Shifrin, R. H. Belmaker

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations

    Abstract

    Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raises levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.

    Original languageEnglish
    Pages (from-to)1463-1467
    Number of pages5
    JournalJournal of Neural Transmission
    Volume103
    Issue number12
    DOIs
    StatePublished - 1 Dec 1996

    Keywords

    • Cyclic AMP
    • Depression
    • Forskolin
    • Schizophrenia

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Psychiatry and Mental health
    • Biological Psychiatry

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