Abstract
Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raises levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1463-1467 |
| Number of pages | 5 |
| Journal | Journal of Neural Transmission |
| Volume | 103 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Dec 1996 |
Keywords
- Cyclic AMP
- Depression
- Forskolin
- Schizophrenia
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
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