Abstract
A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.
Original language | English |
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Pages (from-to) | 3175-3182 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 579 |
Issue number | 14 |
DOIs | |
State | Published - 6 Jun 2005 |
Keywords
- Alpha/beta hydrolase
- Bacillus
- Fold recognition
- ORFans
- Structure prediction
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology