A putative novel alpha/beta hydrolase ORFan family in Bacillus

Naomi Siew, Harpreet Kaur Saini, Daniel Fischer

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.

Original languageEnglish
Pages (from-to)3175-3182
Number of pages8
JournalFEBS Letters
Issue number14
StatePublished - 6 Jun 2005


  • Alpha/beta hydrolase
  • Bacillus
  • Fold recognition
  • ORFans
  • Structure prediction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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