A putative novel alpha/beta hydrolase ORFan family in Bacillus

Naomi Siew; Harpreet Kaur Saini; Daniel Fischer

doi:10.1016/j.febslet.2005.04.030

A putative novel alpha/beta hydrolase ORFan family in Bacillus

Naomi Siew
, Harpreet Kaur Saini
, Daniel Fischer

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.

Original language	English
Pages (from-to)	3175-3182
Number of pages	8
Journal	FEBS Letters
Volume	579
Issue number	14
DOIs	https://doi.org/10.1016/j.febslet.2005.04.030
State	Published - 6 Jun 2005

Keywords

Alpha/beta hydrolase
Bacillus
Fold recognition
ORFans
Structure prediction

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2005.04.030

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title = "A putative novel alpha/beta hydrolase ORFan family in Bacillus",

abstract = "A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.",

keywords = "Alpha/beta hydrolase, Bacillus, Fold recognition, ORFans, Structure prediction",

author = "Naomi Siew and Saini, \{Harpreet Kaur\} and Daniel Fischer",

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doi = "10.1016/j.febslet.2005.04.030",

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T1 - A putative novel alpha/beta hydrolase ORFan family in Bacillus

AU - Siew, Naomi

AU - Saini, Harpreet Kaur

AU - Fischer, Daniel

PY - 2005/6/6

Y1 - 2005/6/6

N2 - A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.

AB - A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.

KW - Alpha/beta hydrolase

KW - Bacillus

KW - Fold recognition

KW - ORFans

KW - Structure prediction

UR - https://www.scopus.com/pages/publications/20444423357

U2 - 10.1016/j.febslet.2005.04.030

DO - 10.1016/j.febslet.2005.04.030

M3 - Article

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AN - SCOPUS:20444423357

SN - 0014-5793

VL - 579

SP - 3175

EP - 3182

JO - FEBS Letters

JF - FEBS Letters

IS - 14

ER -

A putative novel alpha/beta hydrolase ORFan family in Bacillus

Abstract

Keywords

ASJC Scopus subject areas

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