A review of chromium (Cr) epigenetic toxicity and health hazards

Mahalaxmi Iyer, Uttpal Anand, Saranya Thiruvenkataswamy, Harysh Winster Suresh Babu, Arul Narayanasamy, Vijay Kumar Prajapati, Chandan Kumar Tiwari, Abilash Valsala Gopalakrishnan, Elza Bontempi, Christian Sonne, Damià Barceló, Balachandar Vellingiri

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Carcinogenic metals affect a variety of cellular processes, causing oxidative stress and cancer. The widespread distribution of these metals caused by industrial, residential, agricultural, medical, and technical activities raises concern for adverse environmental and human health effects. Of these metals, chromium (Cr) and its derivatives, including Cr(VI)-induced, are of a public health concern as they cause DNA epigenetic alterations resulting in heritable changes in gene expression. Here, we review and discuss the role of Cr(VI) in epigenetic changes, including DNA methylation, histone modifications, micro-RNA changes, biomarkers of exposure and toxicity, and highlight prevention and intervention strategies to protect susceptible populations from exposure and adverse occupational health effects. Cr(VI) is a ubiquitous toxin linked to cardiovascular, developmental, neurological, and endocrine diseases as well as immunologic disorders and a high number of cancer types in humans following inhalation and skin contact. Cr alters DNA methylation levels as well as global and gene-specific histone posttranslational modifications, emphasizing the importance of considering epigenetics as a possible mechanism underlying Cr(VI) toxicity and cell-transforming ability. Our review shows that determining the levels of Cr(VI) in occupational workers is a crucial first step in shielding health problems, including cancer and other disorders. More clinical and preventative measures are therefore needed to better understand the toxicity and safeguard employees against cancer.

Original languageEnglish
Article number163483
JournalScience of the Total Environment
Volume882
DOIs
StatePublished - 15 Jul 2023

Keywords

  • Cancerous cells
  • Cr(VI)
  • DNA methylation
  • Epigenetics
  • Histone modifications
  • miRNA

ASJC Scopus subject areas

  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering
  • Environmental Chemistry

Fingerprint

Dive into the research topics of 'A review of chromium (Cr) epigenetic toxicity and health hazards'. Together they form a unique fingerprint.

Cite this