A safe strategy to decrease fetal lead exposure in a woman with chronic intoxication

Adi Leiba, Howard Hu, Amin Zheng, Stefanos N. Kales

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development. The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established. We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We (a) advised her to delay conception until 'toxicological clearance', (b) treated her with multiple courses of lead chelator, DMSA, and (c) prescribed oral calcium. Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure.

Original languageEnglish
Pages (from-to)932-934
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume23
Issue number8
DOIs
StatePublished - 1 Aug 2010
Externally publishedYes

Keywords

  • DMSA
  • Lead
  • chelation

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