A scientific review of gold containing herbo-mineral preparation: Makaradhwaja

Sanjay B. Khedekar, P. K. Prajapati, R. Galib, B. Patgiri

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Makaradhwaja is a popular medicine of Ayurveda used for vigor and vitality. It is mentioned in classical texts of Rasashastra that Makaradhwaja increases longitivity of life and contest aging process. It is used internally for wide range of disorders like Jwara (fever), Prameha (diabetes mellitus), Agnimandya (loss of appetite) etc. Makaradhwaja is gold containing mercurial preparation. As it is prepared by using metals like Swarna (gold), Gandhaka (sulfur) and heavy metal like Parada (mercury) with adopting typical procedure of Kupipakwa Rasayana. As it is containing heavy metal like mercury, different issues arises regarding its safety and toxicity. Here an attempt made to review work carried out on Makaradhwaja for its different aspects like literary, pharmaceutical, analytical experimental and clinical studies. By screening all the relevant classical texts of Rasashastra and scientific work available it was found that Makaradhwaja not only safe but also therapeutically effective in disorders like diabetes mellitus, rheumatoid arthritis etc.

Original languageEnglish
Pages (from-to)S7-S11
JournalInternational Journal of Green Pharmacy
Issue number4
StatePublished - 1 Jan 2015
Externally publishedYes


  • Chandrodaya rasa
  • Makaradhwaja
  • Mercury sulfide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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