A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding

Keyphrases

• 4-step 33%
• Binding Analysis 33%
• Binding Stoichiometry 33%
• Causative Agents 33%
• Commercially Available 33%
• CTG Repeat 66%
• CUG Repeats 66%
• High-affinity Binding 33%
• IC50 Value 33%
• Isothermal Titration Calorimetry 33%
• Job Analysis 33%
• Muscleblind-like 100%
• Myotonic Dystrophy 33%
• Negative Cooperativity 33%
• Oligonucleotides 33%
• Protein Binding 100%
• Rational Design 33%
• RNA Complexes 66%
• RNA Repeats 33%
• RNA-protein Complex 33%
• Sequence of Steps 33%
• Sequester 33%
• Sex-lethal 33%
• T-match 100%
• Transfer RNA (tRNA) 33%
• Trinucleotide Repeats 100%

Biochemistry, Genetics and Molecular Biology

• Binding Affinity 20%
• Binding Protein 100%
• Cooperation 20%
• IC50 20%
• Isothermal Titration Calorimetry 20%
• Oligonucleotide 20%
• Protein Complexes 20%
• RNA 100%
• Stoichiometry 20%
• Transfer RNA 20%
• Trinucleotide Repeat Expansion 100%