A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Paulina M. Wojnarowicz; Raquel Lima e Silva; Masayuki Ohnaka; Sang Bae Lee; Yvette Chin; Anita Kulukian; Sung Hee Chang; Bina Desai; Marta Garcia Escolano; Riddhi Shah; Marta Garcia-Cao; Sijia Xu; Rashmi Kadam; Yehuda Goldgur; Meredith A. Miller; Ouathek Ouerfelli; Guangli Yang; Tsutomu Arakawa; Steven K. Albanese; William A. Garland; Glenn Stoller; Jaideep Chaudhary; Larry Norton; Rajesh Kumar Soni; John Philip; Ronald C. Hendrickson; Antonio Iavarone; Andrew J. Dannenberg; John D. Chodera; Nikola Pavletich; Anna Lasorella; Peter A. Campochiaro; Robert Benezra

doi:10.1016/j.celrep.2019.08.073

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. GarlandGlenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.

Original language	English
Pages (from-to)	62-75.e7
Journal	Cell Reports
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2019.08.073
State	Published - 1 Oct 2019
Externally published	Yes

Keywords

Id proteins
angiogenesis
macular degeneration
protein-protein interactions
retinopathy of prematurity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2019.08.073

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Wojnarowicz, P. M., Lima e Silva, R., Ohnaka, M., Lee, S. B., Chin, Y., Kulukian, A., Chang, S. H., Desai, B., Garcia Escolano, M., Shah, R., Garcia-Cao, M., Xu, S., Kadam, R., Goldgur, Y., Miller, M. A., Ouerfelli, O., Yang, G., Arakawa, T., Albanese, S. K., ... Benezra, R. (2019). A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Reports, 29(1), 62-75.e7. https://doi.org/10.1016/j.celrep.2019.08.073

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title = "A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization",

abstract = "Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.",

keywords = "Id proteins, angiogenesis, macular degeneration, protein-protein interactions, retinopathy of prematurity",

author = "Wojnarowicz, {Paulina M.} and {Lima e Silva}, Raquel and Masayuki Ohnaka and Lee, {Sang Bae} and Yvette Chin and Anita Kulukian and Chang, {Sung Hee} and Bina Desai and {Garcia Escolano}, Marta and Riddhi Shah and Marta Garcia-Cao and Sijia Xu and Rashmi Kadam and Yehuda Goldgur and Miller, {Meredith A.} and Ouathek Ouerfelli and Guangli Yang and Tsutomu Arakawa and Albanese, {Steven K.} and Garland, {William A.} and Glenn Stoller and Jaideep Chaudhary and Larry Norton and Soni, {Rajesh Kumar} and John Philip and Hendrickson, {Ronald C.} and Antonio Iavarone and Dannenberg, {Andrew J.} and Chodera, {John D.} and Nikola Pavletich and Anna Lasorella and Campochiaro, {Peter A.} and Robert Benezra",

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year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.celrep.2019.08.073",

language = "English",

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Wojnarowicz, PM, Lima e Silva, R, Ohnaka, M, Lee, SB, Chin, Y, Kulukian, A, Chang, SH, Desai, B, Garcia Escolano, M, Shah, R, Garcia-Cao, M, Xu, S, Kadam, R, Goldgur, Y, Miller, MA, Ouerfelli, O, Yang, G, Arakawa, T, Albanese, SK, Garland, WA, Stoller, G, Chaudhary, J, Norton, L, Soni, RK, Philip, J, Hendrickson, RC, Iavarone, A, Dannenberg, AJ, Chodera, JD, Pavletich, N, Lasorella, A, Campochiaro, PA & Benezra, R 2019, 'A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization', Cell Reports, vol. 29, no. 1, pp. 62-75.e7. https://doi.org/10.1016/j.celrep.2019.08.073

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T1 - A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

AU - Wojnarowicz, Paulina M.

AU - Lima e Silva, Raquel

AU - Ohnaka, Masayuki

AU - Lee, Sang Bae

AU - Chin, Yvette

AU - Kulukian, Anita

AU - Chang, Sung Hee

AU - Desai, Bina

AU - Garcia Escolano, Marta

AU - Shah, Riddhi

AU - Garcia-Cao, Marta

AU - Xu, Sijia

AU - Kadam, Rashmi

AU - Goldgur, Yehuda

AU - Miller, Meredith A.

AU - Ouerfelli, Ouathek

AU - Yang, Guangli

AU - Arakawa, Tsutomu

AU - Albanese, Steven K.

AU - Garland, William A.

AU - Stoller, Glenn

AU - Chaudhary, Jaideep

AU - Norton, Larry

AU - Soni, Rajesh Kumar

AU - Philip, John

AU - Hendrickson, Ronald C.

AU - Iavarone, Antonio

AU - Dannenberg, Andrew J.

AU - Chodera, John D.

AU - Pavletich, Nikola

AU - Lasorella, Anna

AU - Campochiaro, Peter A.

AU - Benezra, Robert

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.

AB - Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.

KW - Id proteins

KW - angiogenesis

KW - macular degeneration

KW - protein-protein interactions

KW - retinopathy of prematurity

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SN - 2211-1247

VL - 29

SP - 62-75.e7

JO - Cell Reports

JF - Cell Reports

IS - 1

ER -

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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