A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. GarlandGlenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.

Original languageEnglish
Pages (from-to)62-75.e7
JournalCell Reports
Volume29
Issue number1
DOIs
StatePublished - 1 Oct 2019
Externally publishedYes

Keywords

  • Id proteins
  • angiogenesis
  • macular degeneration
  • protein-protein interactions
  • retinopathy of prematurity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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