A supramolecular multi-block copolymer with a high propensity for alternation

Taiho Park; Steven C. Zimmerman

doi:10.1021/ja064116s

A supramolecular multi-block copolymer with a high propensity for alternation

Taiho Park, Steven C. Zimmerman

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

Alternating, multi-block supramolecular copolymers were created using quadruple hydrogen bonding as the noncovalent binding force. One block consisted of two guanosine butyl urea (UG) units attached at the ends of a triethylene glycol linker or a PEG chain (MW = 2 kD). The other block contained a 2,7-diamido-1,8-naphthyridine (DAN) unit at each end of a short alkane diester linker or a 100 kD poly(butyl methacrylate) macromolecule. The UG unit presents an ADDA hydrogen bonding array that is complementary to the DAAD array of DAN, and these form a very strong complex (K_assoc ∼ 5 × 10⁷ M^-1), whereas UG and DAN weakly self-associate. These recognition properties allowed a multi-block supramolecular polymer to form which exhibits a high propensity for alternation. The self-assembled polymeric structure was shown to be reversibly formed and it was characterized by a combination of dynamic light scattering (DLS), ¹H NMR, size exclusion chromatography (SEC), and viscometry.

Original language	English
Pages (from-to)	13986-13987
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	43
DOIs	https://doi.org/10.1021/ja064116s
State	Published - 1 Nov 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja064116s

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abstract = "Alternating, multi-block supramolecular copolymers were created using quadruple hydrogen bonding as the noncovalent binding force. One block consisted of two guanosine butyl urea (UG) units attached at the ends of a triethylene glycol linker or a PEG chain (MW = 2 kD). The other block contained a 2,7-diamido-1,8-naphthyridine (DAN) unit at each end of a short alkane diester linker or a 100 kD poly(butyl methacrylate) macromolecule. The UG unit presents an ADDA hydrogen bonding array that is complementary to the DAAD array of DAN, and these form a very strong complex (Kassoc ∼ 5 × 107 M-1), whereas UG and DAN weakly self-associate. These recognition properties allowed a multi-block supramolecular polymer to form which exhibits a high propensity for alternation. The self-assembled polymeric structure was shown to be reversibly formed and it was characterized by a combination of dynamic light scattering (DLS), 1H NMR, size exclusion chromatography (SEC), and viscometry.",

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A supramolecular multi-block copolymer with a high propensity for alternation

Abstract

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