A synthetic approach towards the synthesis of asmarine analogues

Doron Pappo; Amira Rudi; Yoel Kashman

doi:10.1016/S0040-4039(01)01111-X

A synthetic approach towards the synthesis of asmarine analogues

Doron Pappo, Amira Rudi, Yoel Kashman

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Asmarines are marine alkaloids with the unique N(10)-hydroxytetrahydro[1,4] diazepino[1,2,3-g,h]purine system and interesting biological activity. The heterotricyclic system was prepared from substituted purines. CH-correlations were found to be an easy way to determine the mode of cyclisation in those cases where more than one is possible, that is, obtaining the tetrahydrodiazepinopurine or tetrahydropyrimidopurine system.

Original language	English
Pages (from-to)	5941-5943
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	34
DOIs	https://doi.org/10.1016/S0040-4039(01)01111-X
State	Published - 20 Aug 2001
Externally published	Yes

Keywords

Asmarines
Diazepinopurine
Marine metabolites
NMR
Pyrimidinopurine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01111-X

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AU - Rudi, Amira

AU - Kashman, Yoel

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AB - Asmarines are marine alkaloids with the unique N(10)-hydroxytetrahydro[1,4] diazepino[1,2,3-g,h]purine system and interesting biological activity. The heterotricyclic system was prepared from substituted purines. CH-correlations were found to be an easy way to determine the mode of cyclisation in those cases where more than one is possible, that is, obtaining the tetrahydrodiazepinopurine or tetrahydropyrimidopurine system.

KW - Asmarines

KW - Diazepinopurine

KW - Marine metabolites

KW - NMR

KW - Pyrimidinopurine

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EP - 5943

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

A synthetic approach towards the synthesis of asmarine analogues

Abstract

Keywords

ASJC Scopus subject areas

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