A synthetic approach towards the synthesis of asmarine analogues

Doron Pappo, Amira Rudi, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Asmarines are marine alkaloids with the unique N(10)-hydroxytetrahydro[1,4] diazepino[1,2,3-g,h]purine system and interesting biological activity. The heterotricyclic system was prepared from substituted purines. CH-correlations were found to be an easy way to determine the mode of cyclisation in those cases where more than one is possible, that is, obtaining the tetrahydrodiazepinopurine or tetrahydropyrimidopurine system.

Original languageEnglish
Pages (from-to)5941-5943
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number34
DOIs
StatePublished - 20 Aug 2001
Externally publishedYes

Keywords

  • Asmarines
  • Diazepinopurine
  • Marine metabolites
  • NMR
  • Pyrimidinopurine

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