A Systematic review and meta-analysis of sensate versus non-sensate flaps for the prevention of pressure ulcer recurrence among individuals with spinal cord disease

Pieter R. Zwanenburg, Rick W.A. Verdijk, Oren Lapid, Miryam C. Obdeijn, Sarah L. Gans, Marja A. Boermeester

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Study design: Systematic review and meta-analysis. Objectives: To identify, critically appraise, and synthesize research findings on non-sensate versus sensate flaps among individuals with spinal cord disease and pelvic pressure ulcers, with pressure ulcer recurrence as primary outcome. Methods: PubMed, EMBASE, and Cochrane CENTRAL were screened for relevant studies. Data on surgical characteristics, ulcer recurrence, and sensory outcomes were retrieved and tabulated. Risk of bias was assessed with MINORS. The level of evidence was evaluated with GRADE. Meta-analysis was performed when possible. Results: Meta-analysis of 1794 non-sensate locoregional reconstructions indicated a recurrence rate of 34% within several years (95% CI, 27–42). Twenty-one articles provided data on 75 sensate reconstructions, performed in 74 individuals. Meta-analysis of the sensate reconstructions indicated a recurrence rate of 1% (95% CI, 0–8). Sensate reconstructions were not associated with an increase of wound complications (19%; 95% CI, 7–40) compared with non-sensate ones (34%; 95% CI, 27–42). A very low level of evidence was determined with use of GRADE. Conclusion: Although of a very low-level, the present evidence suggests that restoration of sensory innervation may be an effective intervention for the prevention of pressure ulcer recurrence among individuals with spinal cord disease. A prospective RCT is needed to confirm or refute the results of this systematic review.

Original languageEnglish
Pages (from-to)463-473
Number of pages11
JournalSpinal Cord
Volume59
Issue number5
DOIs
StatePublished - 1 May 2021
Externally publishedYes

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

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