A tale of two polymorphic pharmaceuticals: Pyrithyldione and propyphenazone and their 1937 co-crystal patent

Medicine & Life Sciences

• pyrithyldione 100%
• propyphenazone 83%
• Pharmaceutical Preparations 17%
• X-Ray Diffraction 12%
• Synchrotrons 7%
• Crystallization 6%
• Hypnotics and Sedatives 5%
• Powders 5%
• Microscopy 4%
• Anti-Inflammatory Agents 3%
• Temperature 3%

Engineering & Materials Science

• Drug products 46%
• Crystals 42%
• Crystal structure 27%
• X ray diffraction 14%
• Synchrotrons 9%
• Polymorphism 8%
• Chemical properties 7%
• Microscopic examination 7%
• Physical properties 6%
• Powders 5%
• Temperature 2%

Chemical Compounds

• Propyphenazone 76%
• Pharmaceutical 31%
• Crystal Morphology 14%
• Hypnotic Sedative Agent 10%
• Crystal Structure 10%
• Nonsteroid Antiinflammatory Agent 8%
• Ambient Reaction Temperature 3%
• Drug 3%
• X-Ray Diffraction 3%