A transplantable mouse tumor deficient in cyclic-AMP-dependent protein kinase activity

Jacob Hochman, Aviva Katz, Yacob Weinstein

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A transplantable solid tumor deficient in cyclic-AMP-dependent protein kinase (PK) (ATP: protein phosphotransferase; E.C.2.7.1.37) activity was established in vivo following injection into recipient nude mice of mutant (PK-)S49 mouse lymphoma cells propagated in vitro in suspension culture. Tumor cell growth was not affected by dibutyryl cyclic AMP (DB-cAMP) when transferred back into culture. These results suggest that cyclic AMP (cAMP) is not essential for cellular growth both in vitro and in vivo. In addition it is suggested that the absence of cAMP dependent protein kinase is related to the tumorigenicity of the cells by rendering them less controlable by environmental stimuli in the host.

Original languageEnglish
Pages (from-to)11-13,15-16
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number1
DOIs
StatePublished - 1 Jan 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (all)

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