A twin study of human red blood cell catechol O methyl transferase

L. Grunhaus, R. Ebstein, R. Belmaker, S. G. Sandler, W. Jonas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Significant sibling sibling and within family correlations of human red blood cell catechol o methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine related enzyme. However, family studies do not disentangle genetic from environmental similarities as causative of within family correlations. The authors therefore undertook a human twin study using the monozygotic dizygotic comparison method. 12 pairs of monozygotic twins had an intraclass correlation of .90 in red blood cell catechol o methyl transferase activity, and 7 pairs of dizygotic twins had an intraclass correlation of .37. Heritability of the enzyme activity was estimated by different methods as between 68-100%.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalBritish Journal of Psychiatry
Volume128
Issue number5
DOIs
StatePublished - 1 Jan 1976
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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