A Versatile Pd-Catalyzed Alkyne Annulation Process for Benzo[ a]carbazoles and their Anticancer Analogues

Manashi Sarmah, Deep Jyoti Das, Dhiraj Dutta, Rinku Baishya, Pranjal Gogoi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A Pd-catalyzed, simple, and divergent approach for the direct synthesis of benzo[a]carbazoles from internal alkynes and N-tosyl-iodoindoles has been demonstrated. This methodology highlights the influences of reaction media and temperature for the synthesis of either N-protected or N-deprotected benzo[a]carbazoles. This cascade strategy provides a series of electronically different benzo[a]carbazoles with good yields. The synthesized benzo[a]carbazoles were evaluated for in vitro anticancer activity against human lung cancer A549 cells and human breast cancer MDA-MB-231 cells. Notably, two of the representative analogues displayed potent anticancer activity against both cancer cell lines.

Original languageEnglish
Pages (from-to)47680-47700
Number of pages21
JournalACS Omega
Volume7
Issue number51
DOIs
StatePublished - 27 Dec 2022
Externally publishedYes

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Chemistry

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