A virus spotlighted by an autonomous DNA machine

Yossi Weizmann, Moritz K. Beissenhirtz, Zoya Cheglakov, Roni Nowarski, Moshe Kotler, Itamar Willner

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

(Chemical Equation Presented) Highly sensitive: Analysis of viral DNA (M13 phage) is possible by using a DNA-based machine that is fueled by dNTPs and synthesizes DNAzyme reporter units. The DNAzymes mimic peroxidase and lead to a colorimetric or chemiluminescent readout of the analyzed DNA.

Original languageEnglish
Pages (from-to)7384-7388
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number44
DOIs
StatePublished - 13 Nov 2006
Externally publishedYes

Keywords

  • Biosensors
  • Chemiluminescence
  • DNA structures
  • DNAzymes
  • Enzymes

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