TY - JOUR
T1 - Abdominal fat sub-depots and energy expenditure
T2 - Magnetic resonance imaging study
AU - Serfaty, Dana
AU - Rein, Michal
AU - Schwarzfuchs, Dan
AU - Shelef, Ilan
AU - Gepner, Yftach
AU - Bril, Nitzan
AU - Cohen, Noa
AU - Shemesh, Elad
AU - Sarusi, Benjamin
AU - Kovsan, Julia
AU - Kenigsbuch, Shira
AU - Chassidim, Yoash
AU - Golan, Rachel
AU - Witkow, Shula
AU - Henkin, Yaakov
AU - Stampfer, Meir J.
AU - Rudich, Assaf
AU - Shai, Iris
N1 - Publisher Copyright:
© 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Background & aims We aimed to assess the association between the distinct abdominal sub-depots and resting energy expenditure (REE). Methods We performed magnetic resonance imaging (MRI) to quantify abdominal visceral-adipose-tissue (VAT), deep-subcutaneous-adipose-tissue (deep-SAT), and superficial-subcutaneous-adipose-tissue (superficial-SAT). We measured REE by indirect-calorimetry. Non-exercise activity thermogenesis (NEAT) [1–3 metabolic equivalents (METs)] and exercise thermogenesis (activities of 4+METS) were estimated based on 6-days of accelerometry to assess total physical activity energy expenditure (PAEE). Results We studied 282 participants: 249 men [mean age = 47.4 years, body-mass-index (BMI) = 31 kg/m2, mean VAT proportion from total abdominal fat = 34.5%, mean superficial-SAT proportion from total abdominal fat = 24.3%] and 33 women (mean age = 51.2 years, BMI = 30.1 kg/m2, mean VAT proportion from total abdominal fat = 22.8%, mean superficial-SAT proportion from total abdominal fat = 37.8%). As expected, women had lower REE [by 32.4% (1488 ± 234 kcal/day vs. 1971 ± 257 kcal/day; p < 0.01)] and lower REE/kg [by 8% (19.6 ± 3 kcal/kg vs. 21.2 ± 2 kcal/kg; p < 0.01)] than men. Exercise and total PAEE were positively associated with REE/kg (p < 0.01 for both) and a positive correlation between NEAT and REE/kg was borderline (p = 0.056). Participants, in whom abdominal VAT was the dominant proportional depot, had higher REE (1964 ± 297 kcal/day vs. 1654 ± 352 kcal/day; p < 0.01) and higher REE∖kg (22.2 ± 2.3 kcal/kg/day vs. 19.6 ± 2.5 kcal/kg/day; p < 0.01) than participants in whom superficial-SAT was the largest proportional depot. In multivariate models, adjusted for age, gender and residual BMI, increased VAT proportion was independently associated with higher REE (β = 0.181; p = 0.05). Likewise, increased VAT proportion (β = 0.482; p < 0.01) remained independently associated with higher REE/kg. In this model younger age (β = −0.329; p < 0.01) was associated with higher REE/kg. Conclusions Abdominal fat distribution patterns are associated with varying levels of resting energy expenditure, potentially reflecting different metabolic rates of adipose sub-depots and providing an anatomic/anthropometric link to physiological obese sub-phenotypes.
AB - Background & aims We aimed to assess the association between the distinct abdominal sub-depots and resting energy expenditure (REE). Methods We performed magnetic resonance imaging (MRI) to quantify abdominal visceral-adipose-tissue (VAT), deep-subcutaneous-adipose-tissue (deep-SAT), and superficial-subcutaneous-adipose-tissue (superficial-SAT). We measured REE by indirect-calorimetry. Non-exercise activity thermogenesis (NEAT) [1–3 metabolic equivalents (METs)] and exercise thermogenesis (activities of 4+METS) were estimated based on 6-days of accelerometry to assess total physical activity energy expenditure (PAEE). Results We studied 282 participants: 249 men [mean age = 47.4 years, body-mass-index (BMI) = 31 kg/m2, mean VAT proportion from total abdominal fat = 34.5%, mean superficial-SAT proportion from total abdominal fat = 24.3%] and 33 women (mean age = 51.2 years, BMI = 30.1 kg/m2, mean VAT proportion from total abdominal fat = 22.8%, mean superficial-SAT proportion from total abdominal fat = 37.8%). As expected, women had lower REE [by 32.4% (1488 ± 234 kcal/day vs. 1971 ± 257 kcal/day; p < 0.01)] and lower REE/kg [by 8% (19.6 ± 3 kcal/kg vs. 21.2 ± 2 kcal/kg; p < 0.01)] than men. Exercise and total PAEE were positively associated with REE/kg (p < 0.01 for both) and a positive correlation between NEAT and REE/kg was borderline (p = 0.056). Participants, in whom abdominal VAT was the dominant proportional depot, had higher REE (1964 ± 297 kcal/day vs. 1654 ± 352 kcal/day; p < 0.01) and higher REE∖kg (22.2 ± 2.3 kcal/kg/day vs. 19.6 ± 2.5 kcal/kg/day; p < 0.01) than participants in whom superficial-SAT was the largest proportional depot. In multivariate models, adjusted for age, gender and residual BMI, increased VAT proportion was independently associated with higher REE (β = 0.181; p = 0.05). Likewise, increased VAT proportion (β = 0.482; p < 0.01) remained independently associated with higher REE/kg. In this model younger age (β = −0.329; p < 0.01) was associated with higher REE/kg. Conclusions Abdominal fat distribution patterns are associated with varying levels of resting energy expenditure, potentially reflecting different metabolic rates of adipose sub-depots and providing an anatomic/anthropometric link to physiological obese sub-phenotypes.
KW - Deep-subcutaneous-adipose-tissue
KW - Non-exercise activity thermogenesis
KW - Resting energy expenditure
KW - Superficial-subcutaneous-adipose-tissue
KW - Visceral-adipose-tissue
UR - http://www.scopus.com/inward/record.url?scp=84973557349&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2016.05.009
DO - 10.1016/j.clnu.2016.05.009
M3 - Article
C2 - 27288327
AN - SCOPUS:84973557349
SN - 0261-5614
VL - 36
SP - 804
EP - 811
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 3
ER -
