Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

R. Wallich; N. Bulbuc; G. J. Hämmerling; S. Katzav; S. Segal; M. Feldman

doi:10.1038/315301a0

Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

R. Wallich
, N. Bulbuc
, G. J. Hämmerling
, S. Katzav
, S. Segal
, M. Feldman

Research output: Contribution to journal › Article › peer-review

385 Scopus citations

Abstract

H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Nature
Volume	315
Issue number	6017
DOIs	https://doi.org/10.1038/315301a0
State	Published - 1 Dec 1985
Externally published	Yes

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title = "Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection",

abstract = "H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.",

author = "R. Wallich and N. Bulbuc and H{\"a}mmerling, \{G. J.\} and S. Katzav and S. Segal and M. Feldman",

year = "1985",

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T1 - Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

AU - Wallich, R.

AU - Bulbuc, N.

AU - Hämmerling, G. J.

AU - Katzav, S.

AU - Segal, S.

AU - Feldman, M.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

AB - H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

UR - https://www.scopus.com/pages/publications/0021815478

U2 - 10.1038/315301a0

DO - 10.1038/315301a0

M3 - Article

C2 - 3873616

AN - SCOPUS:0021815478

SN - 0028-0836

VL - 315

SP - 301

EP - 305

JO - Nature

JF - Nature

IS - 6017

ER -

Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

Abstract

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UN SDGs

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